I have been using Neprinol for a number of years to treat problems with my spine. Product seems work well and provides more comfort than products like Relief Factor.Months after knee replacement, I continued to have a great deal of pain. The first bottle was a gift from a friend who had been helped by it. It turned the pain off!! (Which meant it was due to inflammation.) Enzymes need to be “built up” too work. I started with the 9 per day and have backed off to 4. I could not get enough in on an empty stomach so added them to my daily supplements, which I take with food. It still works. I let them lapse, to verify that they work, and found myself having aches & pains I don’t have with them. For me, these are “Wow!”I have tried blood thinners and they were impossible to balance. I have PVT and hate blood thinners and risk associated with them. This is by far the best remedy I've found to remove and prevent blood clots from occurring - period. I am tall , 67 yrs old and take 3-4 capsules on empty stomach day and night. I had a blood clot from the top of my leg to my heel that was scary. Determined not to miss my trip to Cancun, I searched everything I could find on the internet about natural remedies. I found many but the main long term solutions was Neprinol. I took this 3 X a day at first along with other natural remedies and within 3 wks the blood clot that literally was 3 ft long gradually disappeared. I made that trip to Cancun with no problems. Since I turned 50 yrs old I have had blood clotting problems PVTS - but not any more. Docs won't tell you about this Natural fiber enzyme remedy...and, in fact, so far, none of the Docs I have mentioned this to have heard of it. They write the name down, but they like to prescribe drugs sadly. In my book....this is absolutely a miracle cure. If you have blood clots or PVT - don't hesitate- try this. I ran out once and started to get a clot...Immediately reordered and boom...3 days clot gone. It is really expensive and my insurance doesn't pay for this - darn it. I wish there was something as good that was less expensive. I wish I had taken a pic of the 3 ft. long blood clot. Wow...what a miracle.I have had fibroid events throughout my body. This product has greatly reduced this and I will continue to take it for maintenance.Excellent for reducing scar tissue with regular dosing daily for 6-12 monthspeople dont understand the reason for enzymes, that is because most doctors don't know and can't explain. Simply, as we get older our bodies work less efficiently, especially with the horrible food choices we make and the constant stress we are under these days. As result, our bodies will try to create a internal balance, with that we are clueless of the struggles going internally. One of the side effects is inflammation, such as in bowels, which can lead to constipation or diarrhea, yuck. they say, over time untreated inflammation turns chronic. Taking enzymes over time helps with reduction of inflammation in the body,helping the body achieve a more successful internal balance. Remember the word going round is that chronic inflammation can lead to cancer. I don't know if that is true, but most of us are trying to avoid cancer if possible. I have been taking another brand for years, which i loved, however I found Neprinol and was curious and purchased it on sale of course! I take big doses because there is nothing harmful in this product. I look for this product on sale and can usually find a somewhat decent price, I wish the product came with more than 300 capsules because everyone is different and doses can vary for each individual. While I know this product may be out of some people's price range,the fact that it is a bigger bottle is helpful and some enzymes are better than no enzymes, so please give it a try.I am hoping to shrink uterine fibroids. I started taking Neprinol 4 weeks ago. The 1st day I took 2 capsules 3X per day for 2 days. The 3rd day I took 3 capsules 3X per day for 2 days. The 5th day 4 capsules 3X per day. The 7th day 6 capsules 3X per day. The 3rd day I experienced minor cramps and a discharge like a menstrual cycle that lasted for 3 days. I have not had any other discharge of this type.During the 4th week I experienced stomach aches and diarrhea every day. I reduced the dosage to 5 capsules 3X per day, but the stomach aches continued. Reduced the dose to 2 capsules 3X per day. No more stomach aches or diarrhea!My fibroids are not large, but I can feel the largest 1 (5 cm) due to it's location. I will have a procedure in a week and will know if the fibroid is smaller or gone. Will repost then.5 week updateAfter using Nepronil for 5 weeks, I had a procedure. The doctor was able to see only 1 fibroid and it was 2 cm!! This stuff works!!!!! I will continue to use a maintenance dosage of 2 pills 2X per day. The fibroids are no longer a concern, but I believe systemic enzymes are necessary.After turning 65, I needed a serious body cleanse .Years ago, I recommended this to a very good friend of mine who then testified to me about the goodness of the cleansing power of Neprinol, that’s why I used it. I cannot tell exactly what it cleansed on me but I can feel my body lighter, a lot of trips to the bathroom at night to pee intensively....It is very costly, many pills to swallow every day, at least easy to swallow, for that price the manufacturer should really give more details about the product.Overall I liked it though.I’ll buy again.Product is as described.